详 情

• 介绍

  本科1991年毕业于山东大学， 1998年硕士研究生毕业于北京协和医科大学， 2004年博士研究生毕业于荷兰格罗宁根大学生物化学系， 2005-20011年在美国的avid Kaplan研究组进行博士后研究。 20011年11月进入苏州大学现代丝绸国家工程实验室工作，曾先后任职荷兰BioMaDe生物技术公司、美国ETEX生物技术公司、Ekteino Laboratories生物技术公司，长期从事可降解生物材料在组织工程和药物递送方面的基础和应用研究，在国际知名刊物Protein Science、Biomaterials、Journal of Controlled Release、Macromolecular Bioscience等发表相关论文二十余篇，世界专利六篇。2012年被聘为苏州大学-美国Tufts大学联合实验室主任。

• 应用方向

  丝素蛋白基药物缓释及组织修复；功能化丝素蛋白生物材料

• 技术成果

  近五年发表的代表性论文和教材 2014-2017发表论文： 1. Wu J, Xie X, Zheng Z, Li G, Wang Y, Wang X*. Effect of pH on polyethylene glycol (PEG)-induced silk microsphere formation for drug delivery. Materials Science and Engineering: C Materials for Biological Applications. 2017 Nov 1;80:549-557. 2. Liu Y, Zheng Z, Guo S, Li G, Wang X*, Kaplan DL. DNA preservation in silk. Biomaterials Science. 2017 Jun 27;5(7):1279-1292. 3. Yang L, Zheng Z, Qian C, Wu J, Liu Y, Guo S, Li G, Liu M, Wang X, Kaplan DL. Curcumin-functionalized silk biomaterials for anti-aging utility. J Colloid Interface Sci. 2017;496:66-77 (SCI, IF: 3.368) 4. Luo T, Yang L, Wu J, Zheng Z, Li G, Wang X*, Kaplan DL. Stabilization of Natural Antioxidants by Silk Biomaterials. ACS Appl Mater Interfaces. 2016;8:13573-13582. doi: 10.1021/acsami.6b01636. Epub 2016 May 17. PMID: 27139741 (SCI, IF: 7.145; Field-Weighted Citation Impact: 0.83; cited number: 2) 5. Wu J, Zheng Z, Li G, Kaplan DL, Wang X*. Control of silk microsphere formation using polyethylene glycol (PEG). Acta Biomaterialia. 2016;39:156-168. doi: 10.1016/j.actbio.2016.05.019. Epub 2016 May 12. PMID: 27181879 (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.98; cited number: 3) 6. Zheng Z, Guo S, Liu Y, Wu J, Li G, Liu M, Wang X*, Kaplan D. Lithium-free processing of silk fibroin. J Biomater Appl. 2016;31:450-463. doi: 10.1177/0885328216653259. Epub 2016 Jun 12. PMID: 27298185 (SCI, IF: 2.764; Field-Weighted Citation Impact: 0; cited number: 0) 7. Yu D，Sun C, Zheng Z, Wang X, Chen D, Wu H, Wang X*, Shi F. Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel. Int J Pharm. 2016;503:229-237. doi: 10.1016/j.ijpharm.2016.02.048. Epub 2016 Mar 10. PMID: 26972377 (SCI, IF: 3.65; Field-Weighted Citation Impact: 5.03; cited number: 3) 8. Li G, Li F, Zheng Z, Luo T, Liu J, Wu J, Wang X*, Kaplan DL. Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. J Mater Sci. 2016;51:3025-3035 (SCI, IF: 2.302; Field-Weighted Citation Impact: 2.17; cited number: 2) 9. Wang Y, Liang M, Zheng Z, Shi L, Su B, Liu J, Kaplan DL, Zhang B, Wang X*. Adhesion Prevention after Laminectomy using Silk-polyethylene glycol (PEG) Hydrogels. Adv Healthc Mater. 2015;4:2120-2127 Aug 24. doi: 10.1002/adhm.201500392. [Epub ahead of print] PMID: 26386268 (SCI, IF: 5.76; Field-Weighted Citation Impact: 0.33; cited number: 1) 10. Lu D, Zheng Z, Guo S, Wang C, Kaplan DL, Wang X*. Binding quantum dots to silk biomaterials for optical sensing. J Sensors. 2015:819373 (SCI, IF: 0.712; Field-Weighted Citation Impact: 0.45; cited number: 1) 11. Zheng Z, Liu M, Guo S, Wu J, Lu D, Li G, Liu S, Wang X*, Kaplan DL. Incorporation of quantum dots in silk biomaterials for fluorescence imaging. J Mater Chem B Mater Biol Med. 2015;3:6509-6519. PMID: 26257913 PMCID: PMC4527682 (SCI, IF: 4.872; Field-Weighted Citation Impact: …; cited number: 3) 12. Li G, Liu J, Zheng Z, Wang X*, Kaplan DL. Structural Mimetic Silk Fiber-Reinforced Composite Scaffolds Using Multi-Angle Fibers. Macromol Biosci. 2015;15:1125-1133. doi: 10.1002/mabi.201400502. Epub 2015 Apr 16. PMID: 25879693 (SCI, IF: 3.85; Field-Weighted Citation Impact: 0.54; cited number: 2) 13. Li G, Li Y, Chen G, He J, Han Y, Wang X*, Kaplan DL. Silk-based biomaterials in biomedical textiles and fiber-based implants. Adv Healthc Mater. 2015;4:1134-1151 doi: 10.1002/adhm.201500002. Epub 2015 Mar 13. PMID: 25772248 PMCID: PMC4456268 (SCI, IF: 5.76; Field-Weighted Citation Impact: 1.3; cited number: 11) 14. Lovett ML, Wang X, Yucel T, York L, Keirstead M, Haggerty L, Kaplan DL. Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics. Eur J Pharm Biopharm. 2015;95:271-278 doi: 10.1016/j.ejpb.2014.12.029. Epub 2015 Jan 12. PMID: 25592326 (SCI, IF: 4.245; Field-Weighted Citation Impact: 3.07; cited number: 9) 15. Wang X*, Partlow B, Liu Jian, Zheng Z, Su Bo, Wang Y, Kaplan D. Injectable silk-polyethylene glycol hydrogels. Acta Biomaterialia. 2015;12:51-61 doi: 10.1016/j.actbio.2014.10.027. Epub 2014 Oct 25. PMID: 25449912 (SCI, IF: 6.025; Field-Weighted Citation Impact: 3.9; cited number: 15) 16. Zhou Shun, Huang Wenwen, Belton David J, Simmons Leo O, Perry Carole C, Wang X, Kaplan DL. Control of bioinspired silicification by genetically engineered fusion proteins: silk - silica binding peptides (SiBPs). Acta Biomaterialia. 2015;15:173-180 doi: 10.1016/j.actbio.2014.10.040. Epub 2014 Nov 4. PMID: 25462851 PMCID: PMC4331239 (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.82; cited number: 7) 17. Li C, Luo T, Zheng Z, Murphy AR, Wang X*, Kaplan DL. Curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells. Acta Biomaterialia. 2015;11:222-232 doi: 10.1016/j.actbio.2014.08.009. Epub 2014 Aug 15. PMID: 25132274 PMCID: PMC4256115 (SCI, IF: 6.025; Field-Weighted Citation Impact: 2.08; cited number: 10) 18. Yin Y, Huang P, Li D, Han Z, Wei G, Zhou C, Wen J, Su B, Wang Y, Wang X*. Collagen nanofibers facilitated presynaptic maturation in differentiated neurons from spinal cord-derived neural stem cells through MAPK/ERK1/2- Synapsin I signaling pathway. Biomacromolecules. 2014;15:2449-2460 doi: 10.1021/bm500321h. Epub 2014 Jul 1. PMID: 24955924 (SCI, IF: 5.75; Field-Weighted Citation Impact: 1.18; cited number: 8) 19. Leng X, Liu B, Su B, Liang M, Shi L, Li S, Qu S, Fu X, Liu Y, Yao M, Wang Y, Wang X*, Kaplan DL. In Situ Ultrasound Imaging of Silk Hydrogel Degradation and Neovascularization. J Tissue Eng Regen Med. 2017;11:822-830; Med. doi: 10.1002/term.1981. Accession number: 25850825 doi: 10.1002/term.1981. Epub 2015 Apr 5. PMID: 25850825 (SCI, IF: 2.37; Field-Weighted Citation Impact: 0.74; cited number: 1) 20. Qing Liu, Shufa Zhou, Zeyu Zhao, Zhaozhu ZHENG, Gang Li, Xiaoqin Wang. SF/polyethylene Glycol nano-fibrous membranes loaded with Curcumin, Thermal Science 2017, 21(4), 21-27. (SCI, IF 0.95) 授权发明专利情况 1 一种可注射丝素蛋白原位凝胶的制备方法及其应用 ZL201310203722.2 发明 授权 2/3 2 一种大分子量丝素蛋白冻干粉的制备工艺 ZL201410118465.7 发明 授权 1/2 3 一种家蚕丝素蛋白溶液制备及鉴定 201510071886.3 发明 实审 1/2 4 一种治疗内耳疾病的控释缓释丝素蛋白凝胶制剂 201520089733.1 发明 实审 1/2 5 一种用于药物控释的丝素-载药纳微米颗粒的制备方法 201510918623.1 发明 实审 1/4 6 一种大分子量丝素蛋白冻干粉、制备工艺及其应用 PCT/CN2015/075019 发明 实审 1/7 7 一种用聚乙二醇制备丝素纳微米球的方法及其在药物控释中的应用 PCT/CN2015/097464 发明 实审 1/3 8 一种三维复合结构肛瘘线及其制备方法 201510468318.7 发明 实审 5/5 9 一种具有纬纱张力控制器的的织机梭子 5834673 实用新型 授权 5/5 10 一种农药残留检测方法及检测试剂盒 201610538541.9 发明 实审 2/3 11 一种利用丝素蛋白对DNA保存的方法及试剂盒 2016103882027 发明 实审 1/2 12 一种小口径圆纬机添纱装置 201610437082.5 发明 实审 5/5 13 一种制备医用管状支架的装置 201510612349.5 发明 实审 7/7